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冠脉内注射降钙素基因相关肽（ＣＧＲＰ）０．３μｇ／ｋｇ，对正常及不同程度冠脉狭窄犬的心功能产生不同影响。结果表明，正常犬冠脉内注射ＣＧＲＰ后，平均动脉压（ＭＡＰ）下降１．２ｋＰａ（Ｐ＜０．０５），同时，心率（ＨＲ）、心输出量（ＣＯ）、左室收缩压峰值（ＬＶＳＰ）均不同程度增加；左室舒张末压（ＬＶＥＤＰ）轻度降低。在中度狭窄３０ｍｉｎ后冠脉内注射ＣＧＲＰ对ＨＲ、ＭＡＰ无明显影响；而重度狭窄后注射ＣＧＲＰ，ＭＡＰ由狭窄时降低逐渐增高，ＨＲ由增快而变慢。ＣＯ、ＬＶＳＰ均显著增高，ＬＶＥＤＰ降低，此作用较冠脉狭窄前更为明显。提示ＣＧＲＰ能扩张冠状动脉，增加冠脉血流量和心排血量，增强心肌收缩力，对缺血心脏功能有保护作用
Coronary injection of calcitonin gene-related peptide (CGRP) 0.3μg / kg, normal and varying degrees of coronary heart disease in dogs have different effects. The results showed that the mean arterial pressure (MAP) decreased 1.2 kPa (P <0.05) after CGRP was injected into the normal dogs. Meanwhile, the values of heart rate (HR), cardiac output LVSP) were increased to varying degrees; left ventricular end-diastolic pressure (LVEDP) decreased slightly. The intracoronary injection of CGRP had no significant effect on HR and MAP after moderate stenosis for 30 min. However, CGRP was decreased after severe stenosis, MAP decreased gradually from stenosis, and HR increased slowly and slowly. CO, LVSP were significantly higher, LVEDP decreased, this effect is more obvious than before coronary stenosis. Tip CGRP can dilate coronary artery, increase coronary blood flow and cardiac output, enhance myocardial contractility, have a protective effect on ischemic heart function