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目的观察汉族人群中,乙醛脱氢酶2(ALDH2)基因Glu487Lys多态性与罹患冠心病危险性之间的关联。方法收集经冠脉造影检查明确诊断且冠脉狭窄≥50%的490名冠心病患者(冠心病组)及明确排除的433名非冠心病患者(对照组),共923例纳入本项研究。ALDH2的Glu487Lys基因多态性由TaqManPCR技术测得,比较ALDH2各基因型在冠心病组与对照组的分布,并根据冠心病危险因素,对该研究进行了亚组分析。结果在所有研究对象中,ALDH2各基因型在冠心病组和对照组分布差异无统计学意义(P=0.22)。但亚组分析显示,在无饮酒史,无吸烟史,无高血压史,BMI<25(kg/m2)4个亚组中,ALDH2各基因型的分布在冠心病组和对照组中差异有统计学意义(P<0.05)。结论 ALDH2基因多态性与中国人群罹患冠心病无显著关系,在单纯无饮酒史,无吸烟史,无高血压史或BMI正常的中国汉族人群中,ALDH2基因AA型与其罹患冠心病可能存在关联。
Objective To investigate the association between ALDH2 gene Glu487Lys polymorphism and risk of coronary heart disease in Chinese Han population. Methods A total of 490 patients with CHD (coronary heart disease) and 433 patients without coronary heart disease (control group) who were correctly diagnosed by coronary angiography and ≥50% coronary stenosis were collected. A total of 923 patients were enrolled in this study. The polymorphism of Glu487Lys gene in ALDH2 was determined by TaqManPCR technique. The distribution of ALDH2 genotypes in CHD group and control group was compared. According to the risk factors of coronary heart disease, the subgroup analysis of this study was performed. Results There was no significant difference in the distribution of ALDH2 genotype between CHD group and control group in all the subjects (P = 0.22). However, in the subgroup analysis, there was no significant difference in the distribution of ALDH2 genotypes in the four subgroups of BMI <25 (kg / m2) without history of alcohol consumption, no smoking history, no history of hypertension, and coronary heart disease Statistical significance (P <0.05). Conclusions ALDH2 gene polymorphism has no significant relationship with coronary heart disease in Chinese population. There may be association between AA genotype of ALDH2 gene and coronary heart disease in Chinese Han population without history of alcohol drinking, no smoking history, no history of hypertension or normal BMI .