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自1972年Jondal 和Wybran 等通过实验得出“E 花环的形成是T 淋巴细胞的独特标志”的结论以来,又经学者们多年的研究,E 花环又有了不少新的进展。现知人T 淋巴细胞存在异质性亚群,由于各种T 细胞亚群对羊红细胞(SRBC)具有不同的亲和力,因此可呈不同程度的结合;形成的E 花环在37℃下又可显示不同程度的稳定性;用促有丝分裂素或特异性抗原刺激淋巴细胞后也可改变其形成E 花环的能力。因此在不同条件下就可形成不同类型的E 花环,同时在临床上具有不同的意义。根据
Since 1972, Jondal and Wybran and other experiments through the conclusion that “the formation of E-garland is a unique marker of T-lymphocytes,” and after years of research by scholars, E-garland has made a lot of new progress. Nowadays there is heterogeneous subpopulation of T lymphocytes, which may show different degrees of binding due to the different affinities of various T cell subpopulations on sheep erythrocytes (SRBC); the formation of E-garland may again show a difference at 37 ° C The degree of stability; stimulation of lymphocytes with mitogen or specific antigen also can change its ability to form E rosette. Therefore, different types of E garlands can be formed under different conditions, meanwhile they have different meanings in clinical practice. according to