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作者对35例慢性阻塞性肺病(COPD)患者进行夜间睡眠时的呼吸状况和血氧饱和度(SaO_2)监测,并与12名健康人对照,结果发现患者睡眠时发生呼吸暂停的次数和时间均明显高于对照组(P<0.001和 P<0.01),同时伴 SaO_2明显下降(P<0.05)。作者还发现 COPD 患者中出现鼻咽部异常者占54%(19/35例),而鼻咽部异常者睡眠中下降的 SaO_2明显低于鼻咽正常者(P<0.05)。因为鼻阻塞和鼻阻力增高时可引起睡眠呼吸的异常和 SaO_2降低,因此认为上气道异常是导致 COPD 患者睡眠呼吸紊乱的原因之一。
The authors monitored the respiratory status and oxygen saturation (SaO_2) in 35 patients with chronic obstructive pulmonary disease (COPD) during nighttime sleep and compared them to 12 healthy people. The results showed that the number and duration of apnea during sleep (P <0.001 and P <0.01), while accompanied with SaO2 significantly decreased (P <0.05). The authors also found that COPD patients with nasopharyngeal abnormalities accounted for 54% (19/35 cases), while nasopharyngeal abnormalities decreased during sleep SaO2 was significantly lower than normal (P <0.05). Because nasal obstruction and increased nasal resistance can cause sleep disordered breathing and reduced SaO 2, so that the upper airway anomalies is one of the causes of sleep disordered breathing in patients with COPD.