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H_(322)为四咪唑(即驱虫净)的中间体之一,湖北省医药工业研究所经调查发现:在四咪唑生产车间工作的工人,血压普遍偏低,患高血压者的症状缓解。据此我们对四咪唑及其中间体 H_(322)进行了降压试验。实验结果证明:H_(322)具有明显的降压作用,从而为合成有效的抗高血压药物提给供了新类型。现将 H_(322)的降压作用,降压机制及
H_(322) is one of the intermediates of tetraimidazole (ie, anthelmintic). According to an investigation conducted by the Institute of Pharmaceutical Industry of Hubei Province, the workers working in tetraimidazole production workshop generally have low blood pressure, and the symptoms of hypertensive patients are relieved. . Based on this, we conducted a hypotensive test on tetraimidazole and its intermediate H_(322). The experimental results show that H_(322) has a significant antihypertensive effect, which provides a new type of synthetic antihypertensive drugs. The hypotensive effect of H_(322), the decompression mechanism, and