血栓闭塞性脉管炎(TAO,Buerger 氏病)是一种以动脉为主、静脉同时受累的慢性进行性全身性血管疾病,以亚洲地区多发。对其病因,国内外学者提出许多学说,但到目前仍未有定论,还在进一步研究过程中。近二十年来,随着免疫学、遗传学的迅猛发展和边缘学科的渗透以及新技术的应用,更加促进了对 TAO 病因机制的探讨。不少学者通过对 TAO 病人的体液免疫、细胞免疫及免疫病理学的研究,认为此病是一种自身免疫性疾病,而自身免疫性疾病多有家族遗传因素存在。所以一些学者进 Thromboangiitis obliterans (TAO, Buerger’s disease) is a predominantly arterial, venous simultaneous chronic systemic vascular disease, with multiple occurrences in Asia. For its cause, scholars from home and abroad put forward many theories, but it is still inconclusive so far and is still undergoing further research. In the recent two decades, with the rapid development of immunology and genetics and the infiltration of marginal subjects and the application of new technologies, the etiology and pathogenesis of TAO have been further promoted. Many scholars through the TAO patients humoral immunity, cellular immunity and immune pathology study, that the disease is an autoimmune disease, and autoimmune diseases and more family genetic factors exist. So some scholars into