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目的探讨胸腺样分化甲状腺癌的临床特征、诊治和预后。方法回顾性分析2007-09-01至2015-09-01复旦大学附属肿瘤医院收治16例胸腺样分化甲状腺癌病人临床资料,包括术前检查、治疗方法、病理学检查和免疫组化检测结果以及预后情况。结果所有病人均行手术治疗,13例行术后放疗。免疫组化检测:CD5、CD117呈阳性,Tg、TTF-1、Calcitonin呈阴性。4例病人失访,12例无进展或死亡[平均随访时间(43.3±28.6)个月]。结论胸腺样分化甲状腺癌恶性程度低、预后良好。CD5、CD117呈阳性能对其进行有效的鉴别诊断。手术是首选治疗方式,术后放疗可能对减少复发有作用。
Objective To investigate the clinical characteristics, diagnosis, treatment and prognosis of thymectoid thyroid carcinoma. Methods The clinical data of 16 patients with thymus-differentiated thyroid cancer admitted to Cancer Hospital of Fudan University from September 2007 to January 2015 were retrospectively analyzed, including the results of preoperative examination, treatment, pathological examination and immunohistochemistry. Prognosis. Results All patients underwent surgical treatment and 13 underwent postoperative radiotherapy. Immunohistochemical detection: CD5, CD117 positive, Tg, TTF-1, Calcitonin was negative. Four patients were lost to follow-up, and no progression or death occurred in 12 patients [mean follow-up (43.3 ± 28.6) months]. Conclusion Thymus-like thyroid carcinoma has a low malignant degree and a good prognosis. CD5, CD117 positive for its effective differential diagnosis. Surgery is the preferred treatment, postoperative radiotherapy may have a role in reducing recurrence.