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目的了解甘肃省下呼吸道感染常见病毒病原及临床表现。方法收集传染病监测信息系统中2010-2013年省内10所哨点医院942例下呼吸道感染病例信息,采集鼻咽拭子/抽吸物、痰、肺泡灌洗液等呼吸道标本及血液、血清、胸腔穿刺液,采用聚合酶链反应法对流感病毒(influenza,Flu)、呼吸道合胞病毒(respiratory syncytial virus,RSV)、腺病毒(adenovirus,Adv)、副流感病毒(parainfluenza virus,PIV)、偏肺病毒(human metapneumovirus,h MPV)和人冠状病毒(human coronavirus,HCo V)进行核酸检测,采用描述性统计学方法分析病例信息、临床表现和病原检测结果。结果 942例病例男女数之比为1.93∶1,年龄中位数为47.73岁,病原检出率为31.32%,多重感染为3.08%,病原检出顺位为Flu(13.63%)、RSV(8.69%)、PIV(4.87%)、HCo V(4.14%)、Adv(2.38%)和h MPV(2.09%),<2岁儿童(217例)中RSV(20.00%)、PIV(10.89%)和Flu(9.43%)居前3位,≥15岁人群(508例)中Flu(15.35%)、HCo V(7.09%)和RSV(5.71%)居前3位。病例主要临床表现为咳嗽(89.81%)、咳痰(64.65%)和发热(58.39%),腹痛、腹泻仅为1.27%、6.26%。结论甘肃省下呼吸道感染病例病毒以Flu、RSV和PIV为主,儿童和成人感染的主要病毒及临床表现均不相同。
Objective To understand the common viral pathogens and clinical manifestations of lower respiratory tract infection in Gansu Province. Methods A total of 942 cases of lower respiratory tract infection in 10 sentinel hospitals in the province from 2010 to 2013 were collected and respiratory specimens such as nasopharyngeal swabs / aspirates, sputum and alveolar lavage were collected, blood and serum , Thoracentesis were used to detect the infection of influenza, Flu, RSV, adenovirus (Adv), parainfluenza virus (PIV), parainfluenza virus Human metapneumovirus (hMPV) and human coronavirus (HCoV) were used for nucleic acid detection. Case information, clinical manifestations and pathogen test results were analyzed using descriptive statistics. Results The ratio of male to female in 942 cases was 1.93:1, the median age was 47.73 years, the detection rate of pathogen was 31.32%, multiple infection was 3.08%, pathogen detection was Flu (13.63%), RSV (8.69 (20.00%) and PIV (10.89%) in PIV (4.87%), HCoV (4.14%), Adv (2.38%) and hMPV (2.09% Flu (15.35%), HCo V (7.09%) and RSV (5.71%) were among the top 3 persons with Flu (9.43%) and the top 3 patients with ≥15 years of age (508 cases). The main clinical manifestations were cough (89.81%), expectoration (64.65%) and fever (58.39%), abdominal pain and diarrhea were only 1.27% and 6.26% respectively. Conclusions The viruses of lower respiratory tract infection in Gansu Province are mainly Flu, RSV and PIV. The main viruses and clinical manifestations of infection in children and adults are different.