前列腺素自首次推荐为堕胎药后,其效果屡经证实。改为局部用药后全身用药的副作用已被克服。妊娠4—6个月时于羊膜腔内一次注入适当剂量的前列腺素E_2或F_(2α)多可使妊娠终止,但此法至今尚不能用于三个月内的妊娠。本法的主要缺点是不全流产的发生率高,因此在门诊或住院病人中往往主张采用负压吸引人工流产法。此法广泛地用于3个月内的妊娠,其技术操作简单、安全,但有时需机械扩张宫颈,使以后妊娠中期发生自然流产的机会增加。为此目前最好有一种选择性强的堕胎药,可自服,且在妊娠刚开始时(月经延迟1—2周或敏感的妊娠试验阳性)即有效。阴道内塞入前列腺素终止极早期妊娠,虽初步 Prostaglandin since the first recommendation for abortion drugs, the effect repeatedly confirmed. The side effects of systemic medication instead of topical have been overcome. 4-6 months of pregnancy in the amniotic cavity once injected with the appropriate dose of prostaglandin E_2 or F_ (2α) and more can terminate the pregnancy, but this method has not yet been used for three months of pregnancy. The main disadvantage of this law is the high incidence of incomplete abortion, and therefore often advocates the use of negative pressure to attract abortion in outpatient or inpatient settings. This method is widely used for pregnancy within 3 months, its technical operation is simple and safe, but sometimes the need to mechanically expand the cervix, so that after the second trimester spontaneous abortion increased chances. For the time being, it is best to have a selective abortifacient that is self-administered and effective at the beginning of pregnancy (menstruation is delayed by 1-2 weeks or when a sensitive pregnancy test is positive). Pins into the vagina to terminate very early pregnancy prostaglandin, although preliminary