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近年来的研究表明血管紧张素Ⅱ(ＡⅡ)能刺激纤溶酶原激活剂抑制剂1(ＰＡＩ1)的合成。相反,血管紧张素转化酶(ＡＣＥ)抑制剂能增加组织型纤溶酶原激活剂(ｔＰＡ)的合成。提示肾素血管紧张素系统和纤溶系统间存在潜在的相互关系。ＡⅡ对纤溶系统作用的机制目前尚不明确。本研究目
In recent years, studies have shown that angiotensin Ⅱ (A Ⅱ) can stimulate the synthesis of plasminogen activator inhibitor 1 (PAI1). In contrast, angiotensin-converting enzyme (ACE) inhibitors increase the synthesis of tissue-type plasminogen activator (tPA). Suggesting a potential correlation between renin-angiotensin system and fibrinolytic system. The mechanism of AⅡ on the fibrinolytic system is not yet clear. The purpose of this study