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目的观察非小细胞肺癌合并原发性高血压患者用含紫杉类方案化疗后血压的变化,并分析血压变化的影响因素,探讨化疗期间血压控制的特殊性。方法对2007年9月～2010年9月收住本科的36例非小细胞肺癌合并原发性高血压患者用含紫杉类方案化疗,用药前均给予预处理,化疗前后对患者的血压水平严密监测,及时处理。收集相关临床资料,分析化疗后血压变化规律及影响因素。结果化疗前10～12h给口服地塞米松后监测血压较前无显著变化(P>0.10)。用紫杉醇化疗后0.5h、1h、2h、3h监测血压较化疗前显著升高(P<0.0001),化疗后第1、2、3、4d血压随时间推移逐渐下降,约至第5、6d左右降至化疗前水平。经适当处理,血压控制平稳,没有1例患者出现高血压危象或低血压休克。结论非小细胞肺癌合并高血压患者给予紫杉类药物化疗可导致患者血压进一步升高,随时间推移血压逐渐降至平稳,化疗期间血压波动情况可进行控制,其影响因素较多,具体机制尚需进一步研究。
Objective To observe the changes of blood pressure in patients with non-small cell lung cancer complicated with essential hypertension treated with taxane-containing chemotherapy and to analyze the influencing factors of blood pressure changes and to explore the particularity of blood pressure control during chemotherapy. Methods Thirty-six patients with non-small cell lung cancer admitted to our hospital from September 2007 to September 2010 with primary hypertension were treated with chemotherapy with taxane, and pretreatment was given before and after treatment. The blood pressure Close monitoring and timely treatment. Relevant clinical data were collected to analyze the changes of blood pressure and its influencing factors after chemotherapy. Results There was no significant difference in blood pressure monitoring before oral administration of dexamethasone 10-12h before chemotherapy (P> 0.10). After chemotherapy with paclitaxel 0.5h, 1h, 2h, 3h monitoring blood pressure was significantly higher than before chemotherapy (P <0.0001), 1,2,3,4d after chemotherapy on blood pressure gradually decreased over time, about to about 5,6d Reduced to pre-chemotherapy levels. After proper treatment, blood pressure control is stable, no one case of hypertensive crisis or hypotensive shock. Conclusions The administration of taxane chemotherapy in patients with non-small cell lung cancer complicated with hypertension can lead to further increase of blood pressure, and the blood pressure gradually decreases to stable over time. The fluctuation of blood pressure during chemotherapy can be controlled with many influencing factors. The specific mechanism Need further study