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应用Ｓ－Ｐ免疫组织化学方法研究６２例肺癌组织中ｐ１６蛋白和ｐ５３蛋白的表达情况，并进行增殖细胞核抗原（ＰＣＮＡ）检测，计算细胞增殖指数（ＰＩ）。结果显示６２例肺癌组织中ｐ１６蛋白和ｐ５３蛋白阳性率分别为５８．１％和５９．７％。腺癌ｐ１６蛋白的阳性率明显高于小细胞癌；ＰＩ分级不同者ｐ１６蛋白表达不同。淋巴结转移阳性组ｐ５３蛋白的表达高于阴性组；不同ＰＩ分级中ｐ５３蛋白的表达不同。提示ｐ１６蛋白低表达和ｐ５３蛋白过表达均有促进肺癌细胞增殖的作用，ｐ１６蛋白的表达与肺癌的细胞分化有关，ｐ５３蛋白过表达对肺癌细胞的转移起重要作用
S-P immunohistochemical method was used to study the expression of p16 protein and p53 protein in 62 cases of lung cancer. Proliferating cell nuclear antigen (PCNA) was detected and the cell proliferation index (PI) was calculated. The results showed that the positive rates of p16 protein and p53 protein in 62 lung cancer tissues were 58.1% and 59.7%, respectively. The positive rate of p16 protein in adenocarcinoma was significantly higher than that of small cell carcinoma; the expression of p16 protein was different in different PI grades. The expression of p53 protein was higher in the positive lymph node metastasis group than in the negative group. The expression of p53 protein was different in different PI grades. It is suggested that the low expression of p16 protein and overexpression of p53 protein may promote the proliferation of lung cancer cells. The expression of p16 protein is related to the cell differentiation of lung cancer. Overexpression of p53 protein plays an important role in the metastasis of lung cancer cells.