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目的:观察阿托品联合东莨菪碱交替使用治疗重度急性有机磷中毒(AOPP)的疗效和临床价值。方法:124例重度AOPP患者在常规治疗基础上,在拮抗胆碱作用方面随机以阿托品(对照组)单独使用或以阿托品联合东莨菪碱(治疗组)交替使用,观察两组昏迷患者平均恢复清醒时间、阿托品化时间、达托品化所需阿托品用量、阿托品总量、阿托品中毒发生率、中间综合征(IMS)发生率、阿托品依赖发生率及死亡率。结果:治疗组昏迷患者平均恢复清醒时间缩短,阿托品化时间缩短及所需阿托品量减少,阿托品总量明显减少,阿托品中毒发生率下降,IMS发生率下降,阿托品依赖发生率下降,死亡率明显下降。结论:以阿托品联合东莨菪碱交替应用抢救重度AOPP,使实际阿托品需要量减少,有利于避免阿托品过量所产生的不良现象出现,提高抢救成功率。
Objective: To observe the curative effect and clinical value of atropine combined with scopolamine in the treatment of severe acute organophosphorus poisoning (AOPP). Methods: A total of 124 patients with severe AOPP were treated with atropine (control group) or atropine combined with scopolamine (treatment group) randomly on the basis of routine treatment. The average recovery time of awake in two groups was observed, Atropisol time, the amount of atropine needed for Dart Tartarization, the total amount of atropine, the incidence of atropine poisoning, the incidence of intermediate syndrome (IMS), the incidence of atropine dependence and mortality. Results: The recovery time of coma in treatment group was shortened, the duration of atropisation was shortened, the amount of atropine required was decreased, the total amount of atropine decreased, the incidence of atropine poisoning decreased, the incidence of IMS decreased, the incidence of atropine dependence decreased, and the mortality decreased significantly . Conclusion: Atropine combined with scopolamine alternate application rescue severe AOPP, so that the actual demand for atropine decreased, help to avoid the adverse effects of atropine overdose, improve the success rate of rescue.