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目的 :观察环孢素软胶囊 (以下简称环孢素 )应用于肾移植病人的疗效和不良反应。方法 :2 4例入选的肾移植病人 ,男性 15例 ,女性 9例 ,年龄34a±s 6a(18～ 6 5a)。给予环孢素 +硫唑嘌呤 +泼尼松三联用药 ,其中环孢素起始剂量 8mg·kg- 1·d- 1,以后依血浓度 ,肝、肾功能调整给药量 ,硫唑嘌呤为 50～ 70mg·d- 1,泼尼松于术后d3给 80mg·d- 1,以后递减至维持量。所有病人使用环孢素 ,时间最长为 15mo ,观察随访期 12mo± 2mo。结果 :2 4例中仅出现 2例不典型急性排斥反应 ,2例ALT轻度升高 ,8例出现震颤 ,2例出现齿龈增生 ,5例多毛。结论 :环孢素软胶囊对肾移植病人具有免疫抑制作用 ,肝毒性小。
Objective: To observe the curative effect and adverse reaction of cyclosporine soft capsule (hereinafter referred to as cyclosporine) in renal transplant patients. Methods: Twenty-four renal transplant recipients were enrolled in this study. There were 15 males and 9 females, with an age of 34a ± s 6a (18 ~ 6 5a). Cyclosporine + azathioprine + prednisone triple therapy, in which the initial dose of cyclosporine 8mg · kg-1 · d-1, after the blood concentration, liver and kidney function to adjust the dose, azathioprine 50 ~ 70mg · d-1, prednisone in the postoperative d3 to 80mg · d-1, then decreased to the maintenance dose. All patients using cyclosporine, the longest time of 15mo, observation follow-up period of 12mo ± 2mo. Results: There were only 2 atypical acute rejection cases in 2 of 4 cases, 2 cases of mild ALT, 8 cases of tremor, 2 cases of gingival hyperplasia and 5 cases of hirsutism. CONCLUSION: Cyclosporine soft capsule has immunosuppressive effect on patients with renal transplantation and low hepatotoxicity.