论文部分内容阅读
目的了解贵州省德江县病毒性脑炎的发病状况、流行病学特征和主要病原体种类,为不明原因病毒性脑炎防治工作提供科学依据。方法对2007～2009年国家级乙脑监测县德江县报告的急性病毒性脑炎病例开展个案调查和随访调查,对报告病例采集的血清和/或脑脊液标本进行乙脑病毒和其他病毒性脑炎病毒感染的实验室检测。结果 (1)2007～2009年德江县共报告急性病毒性脑炎病例137例,年均发病率9.31/10万,病死率10.14%。全年1～12月均有病例发生,但以7、8月份为高发月份(占58.39%),各年龄段人群均有发病,但14岁以下儿童为高发人群(占98.54%),其中7岁以下占54.01%,男女性别之比1.74∶1。(2)采集134例报告病例血清和/或脑脊液标本248份,标本采集率为97.81%。经检测,40例确诊为乙脑病毒感染,报告病例的乙脑实验室确诊率为29.20%;21例确诊为肠道病毒等其他病毒性脑炎病毒感染,报告病例的乙脑以外其他病毒感染实验室确诊率为18.58%。(3)罗斯河病毒和森林病毒IgM抗体阳性率2008年(17.86%)比2007年(5.26%)有较大增加。结论乙脑病毒是该地区最主要的病毒性脑炎病原体,其次是罗斯河病毒和森林病毒、肠道病毒、巨细胞病毒等,应加强防治。
Objective To understand the incidence, epidemiological characteristics and types of major etiological agents of viral encephalitis in Dejiang County, Guizhou Province, and to provide a scientific basis for the prevention and treatment of unexplained viral encephalitis. Methods A case investigation and a follow-up investigation of the reported cases of acute viral encephalitis from 2007 to 2009 in Jijian County of Jiedao County were conducted. JE and other viral encephalitis samples were collected from serum and / or CSF samples collected from reported cases Laboratory testing of virus infection. Results (1) A total of 137 cases of acute viral encephalitis were reported in Dejiang County from 2007 to 2009, with an average annual incidence of 9.31 / 100,000 and a case fatality rate of 10.14%. All cases occurred from January to December of the year, but the incidence was high in July and August (58.39%), and all age groups were affected, but children under 14 years old were high incidence (98.54%), of which 7 54.01% under the age of male and female ratio of 1.74: 1. (2) A total of 248 serum and / or cerebrospinal fluid samples from 134 cases were collected. The collection rate of specimens was 97.81%. After testing, 40 cases were confirmed as JE virus infection, the reported diagnosis of JE laboratory was 29.20%; 21 cases were diagnosed as other viral encephalitis virus such as enterovirus infection, reported cases other than JE virus infection Laboratory diagnosis rate was 18.58%. (3) The positive rate of IgM antibodies to Roth virus and forest virus in 2008 (17.86%) increased greatly compared with that in 2007 (5.26%). Conclusion Japanese encephalitis virus is the most important encephalitogenic pathogen in the area, followed by Ross River virus and forest virus, enterovirus and cytomegalovirus, and so should be strengthened.