对以前有p53抑癌基因和Ki-ras癌基突变的一组卵巢肿瘤分析其成视网膜细胞瘤(Rb)基因的表达。将取自美国国际海军医学中心的59例从良性到恶性各种组织类型的卵巢肿瘤,使用一种特异性抗体经过免疫组化技术测定其Rb蛋白的表达。其中良性囊腺瘤18例,低度恶性(LMP)肿瘤19例,上皮性卵巢癌22例。 结果发现,18例良性囊腺瘤均为一正常型Rb表达。19例LMP肿瘤也为正常Rb表达,它有两种染色特征:①上皮细胞核染色与囊腺瘤相似;②上皮 A group of ovarian tumors that previously had p53 oncogene and Ki-ras oncogene mutations were analyzed for retinoblastoma (Rb) gene expression. Fifty-nine ovarian tumors of various tissue types from benign to malignant originating from the U.S. Naval Medical Center were examined for their Rb protein expression by immunohistochemistry using a specific antibody. Of which benign cystadenoma in 18 cases, 19 cases of low grade (LMP) tumors, 22 cases of epithelial ovarian cancer. The results showed that 18 cases of benign cystadenoma were a normal type Rb expression. 19 cases of LMP tumors are also normal Rb expression, which has two staining features: ① epithelial cell nuclear staining and cystadenoma similar; ② epithelial