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目的探讨体液免疫系统的免疫球蛋白及补体水平变化在不同类型β地中海贫血儿童中的临床诊断价值。方法选择2014年5月—2015年10月在我院儿科确诊及治疗的不同类型β地中海贫血儿童50例为观察组,并选取同期正常体检儿童100例设为对照组。检测两组对象的免疫球蛋白Ig A、Ig M、Ig G以及补体C3、C4水平。结果观察组与对照组比较,Ig A、Ig M水平明显高于对照组(P<0.05),补体C3、C4水平明显低于观察组(P<0.05);观察组不同类型的β地中海贫血的结果中,中重度组的免疫球蛋白水平明显高于轻度组(P<0.05),补体C3、C4水平明显低于轻度组(P<0.05)。结论不同类型不同程度的β地中海贫血儿童,体液免疫功能的表达不一样,监测免疫球蛋白以及补体水平变化,可对不同类型β地中海贫血儿童的诊疗及预后有一定的作用。
Objective To investigate the clinical diagnostic value of immunoglobulin and complement levels in the humoral immune system in children with different types of β thalassemia. Methods Fifty children with different types of β-thalassemia who were diagnosed and treated in our hospital from May 2014 to October 2015 were selected as the observation group and 100 normal children in the same period were selected as the control group. The immunoglobulin Ig A, Ig M, Ig G and complement C3, C4 levels of the two groups were detected. Results Compared with the control group, Ig A and Ig M levels in the observation group were significantly higher than those in the control group (P <0.05), C3 and C4 levels in the observation group were significantly lower than those in the observation group (P <0.05), and different types of β-thalassemia The results showed that the levels of immunoglobulin in moderate and severe group were significantly higher than those in mild group (P <0.05), and the levels of C3 and C4 in complement were significantly lower than those in mild group (P <0.05). CONCLUSION: The expression of humoral immunity is different in different types of children with β-thalassemia. Monitoring the changes of immunoglobulin and complement may play a role in the diagnosis and prognosis of children with different types of β thalassemia.