Due to the energy and resource constraints of a wireless sensor node in a wireless sensor network (WSN), design of energy-efficient multipath routing protocols is a crucial concern for WSN applications. To provide high-quality monitoring information, many WSN applications require high-rate data transmission. Multipath routing protocols are often used to increase the network transmission rate and throughput. Although large-scale WSN can be supported by high bandwidth backbone network, the WSN remains the bottleneck due to resource constraints of wireless sensors and the effects of wireless interference. In this paper, we propose a multipath energy-efficient routing protocol for WSN that considers wireless interference. In the proposed routing protocol, nodes in the interference zone of the discovered path are marked and not allowed to take part in the subsequent routing process. In this way, the quality of wireless communication is improved because the effects of wireless interference can be reduced as much as possible. The network load is distributed on multiple paths instead of concentrating on only one path, and node energy cost is more balanced for the entire wireless network. The routing protocol is simulated in NS2 software. Simulation result shows that the proposed routing protocol achieves lower energy cost and longer network lifetime than that in the literature. Due to the energy and resource constraints of a wireless sensor node in a wireless sensor network (WSN), design of energy-efficient multipath routing protocols is a crucial concern for WSN applications. To provide high-quality monitoring information, many WSN applications require high -rate data transmission. Multipath routing protocols are often used to increase the network transmission rate and throughput. However, large-scale WSN can be supported by high bandwidth backbone network, the WSN remains the bottleneck due to resource constraints of wireless sensors and the effects of Wireless interference. In this paper, we propose a multipath energy-efficient routing protocol for WSN that considers wireless interference. In the proposed routing protocol, nodes in the interference zone of the discovered path are marked and not allowed to take part in the subsequent routing process. In this way, the quality of wireless communication is improved because the effects of wireless interference c The bee reduced as much as possible. The network load is distributed on multiple paths instead of concentrating on only one path, and node energy cost is more balanced for the entire wireless network. The routing protocol is simulated in NS2 software. the proposed routing protocol achieves lower energy cost and longer network lifetime than that in the literature.