从实体瘤中新衍生出来的肿瘤细胞通常对自体的或同种异体的外周血淋巴细胞的溶解作用具有抵抗性。然而,1982年Grimm等证明,当外周血白细胞与含有白细胞介素2的培养基一起温育时便可获得溶解抗NK的新鲜肿瘤靶细胞的能力。这种类型的细胞毒作用称之为淋巴因子激活的杀伤作用。最 Tumor cells that are newly derived from solid tumors are often resistant to lytic effects of autologous or allogeneic peripheral blood lymphocytes. However, Grimm et al., 1982 demonstrated that the ability of lytic anti-NK fresh tumor target cells to be obtained when peripheral blood leukocytes are incubated with interleukin 2-containing media. This type of cytotoxicity is called lymphokine-activated killing. most