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目的：研究胃癌及胃炎组织中多药耐药基因产物P糖蛋白（P－gP）的表达。方法：采用免疫组化方法检测P－gP的分布。结果：各组胃癌及胃炎组织中均有P－gP表达，其中慢性胃炎与管状及乳头状癌、与低分化及未分化癌比较，P＜0．01，差异有显著性意义。印戒细胞癌与低分化及未分化癌比较，P＜0．01，差异有显著性意义。结论：癌组织P－gp表达较慢性胃炎强，但癌组织中P－gP表达不均衡。
Objective: To study the expression of multidrug resistance gene product P-glycoprotein (P-gP) in gastric cancer and gastritis tissues. Methods: The distribution of P-gP was detected by immunohistochemistry. Results: The expression of P-gP in gastric carcinoma and gastritis tissues was found in all groups. There was significant difference between chronic gastritis and tubular and papillary carcinoma, and poorly differentiated and undifferentiated carcinomas, P<0.01. Compared with poorly differentiated and undifferentiated carcinomas, signet-ring cell carcinoma showed a significant difference (P<0.01). Conclusion: The expression of P-gp in cancer tissues is stronger than chronic gastritis, but the expression of P-gp in cancer tissues is not balanced.