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应用正交ｔ值法，以肉芽肿为药效指标，分析复方毛冬青的组方原则及优化剂量组合。结果复方毛冬青中抗肉芽肿药效显著者依次为毛冬青、莪术、北芪、丹参。经ｔ检验Ｐ＜０．０１．ｐ＜０．０５。Ｐ＜０．０５，Ｐ＞０．０５。优化剂量组合是毛冬青４０ｇ、莪术１２ｇ、北芪３０ｇ、丹参２０ｇ。优化剂量组合的复方毛冬青液抗肉芽肿作用与对照组比较，Ｐ＜０．０５。＊ｐ＜０．０１，Ｐ＜０．０５，＊Ｐ＞０．０５。
The orthogonal t-value method and granuloma as the efficacy index were used to analyze the principle of compound Mao Dongqing and optimize the dose combination. Results The significant efficacy of compound Maodongqing in controlling granuloma was Mao Dongqing, Yuzhu, Beijiao and Danshen. The t test P<0.01. p<0.05. P<0.05, P>0.05. The optimized dose combination was Maodongqing 40g, Curcuma 12g, Beijiao 30g, Salvia miltiorrhiza 20g. The compound anti-granulomatous effect of the compound dose of Mao Dongqing was better than that of the control group, P<0.05. *p<0.01, P<0.05, *P>0.05.