论文部分内容阅读
目的探讨血清α-L-岩藻糖苷酶(AFU)和腺苷脱氨酶(ADA)联合检测在2型糖尿病病情控制中的临床意义。方法选取济南市434例2型糖尿病患者和94例正常对照人员进行血清AFU和ADA测定。根据糖化血红蛋白(HbA1c)水平高低,将434例糖尿病患者分为血糖控制不良组(HbA1c>9.0%)、血糖控制一般组(7.0%≤HbA1c<9%)和血糖控制良好组(HbA1c<7.0%),比较2型糖尿病各组和正常对照组间AFU、ADA和相关指标的差异,并分析AFU、ADA与FPG和HbA1c的相关性。结果经单因素方差分析和Pearson相关分析,2型糖尿病患者糖尿病组和血糖控制不良组AFU和ADA活性显著高于正常对照组〔(23.29±2.17)vs(15.37±1.57);(23.61±3.07)vs(14.85±3.64),P<0.05〕,并且与糖化血红蛋白(HbA1c,r AFU=0.348,r ADA=0.385,P<0.01)和空腹血糖水平(FPG,r AFU=0.296,r ADA=0.385,P<0.01)呈正相关。血糖控制一般组和良好组与正常对照组组间差异比较无统计学意义(P>0.05),但是AFU和ADA活性仍高于正常对照组。结论 AFU和ADA在血糖控制不良时明显偏高,并且分别与HbA1c和FPG明显相关,可以作为2型糖尿病血糖控制和病情监测的指标。
Objective To investigate the clinical significance of combined detection of serum α-L-fucosidase (AFU) and adenosine deaminase (ADA) in the control of type 2 diabetes mellitus. Methods 434 patients with type 2 diabetes mellitus and 94 normal controls were selected for the determination of serum AFU and ADA. According to the level of HbA1c, 434 patients with diabetes were divided into two groups: control group (HbA1c> 9.0%), general blood glucose control group (7.0% ≤HbA1c <9%) and blood glucose control group (HbA1c <7.0% ) To compare the differences of AFU, ADA and other related indicators between the two groups of type 2 diabetes mellitus and normal controls and to analyze the correlation between AFU, ADA and FPG and HbA1c. Results The single factor analysis of variance and Pearson correlation analysis showed that the activity of AFU and ADA in type 2 diabetic patients with diabetes and poor glycemic control were significantly higher than those in normal controls [(23.29 ± 2.17) vs (15.37 ± 1.57) vs (23.61 ± 3.07) (14.85 ± 3.64, P <0.05), and there was no significant difference between HbA1c and AF (AFA = 0.348, r ADA = 0.385, P <0.01) and fasting plasma glucose (FPG, r AFU = 0.296, r ADA = P <0.01) was positively correlated. There was no significant difference between the normal control group and the normal control group (P> 0.05), but the activities of AFU and ADA were still higher than those of the normal control group. Conclusions AFU and ADA were significantly higher in patients with poor blood glucose control and were significantly associated with HbA1c and FPG, respectively, which could be used as indicators of glycemic control and condition monitoring in type 2 diabetes mellitus.