目的:探讨药物流行病学研究中的无应答问题,概述其解决方案。方法:分析药物流行病学研究中的无应答问题的产生、影响及其解决措施。结果:分析无应答者的信息,采用事前预防和事后补救两方面对药物流行病学研究中无应答数据进行补救,可获得相对可靠的结果。结论:为了获得可靠的结果,药物流行病学研究中应谨慎对待无应答问题。 OBJECTIVE: To investigate the non-response problem in pharmaceutical epidemiology and to outline its solutions. Methods: To analyze the generation of non-response problems in pharmaceutical epidemiology, its influence and its countermeasures. RESULTS: Relatively reliable results were obtained when non-responders were analyzed for information on non-responders using pre-prevention and after-effects remedies for non-response data in pharmacoepidemiological studies. Conclusion: In order to obtain reliable results, non-response issues should be treated with caution in pharmacoepidemiological studies.