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卡维地洛(简称CDL)是一种新的具有血管扩张作用的非心脏选择性β阻滞剂,治疗心绞痛有效。本文研究本品对原发性高血压患者左室功能、生理试验时的血压及24小时血压的影响。方法:12例原发性高血压病人。停用所有降压药3周后,卧位休息15分钟后的收缩压>160mmHg或舒张压>100mmHg者。先口服CDL25mg每日2次,2周后若舒张压≥95mmHg或治疗前卧位舒张压下降幅度未达20mmHg以上者,则加大CDL剂量至50mg每日2次,维持2周。在治疗前、首剂2小时后及治疗结束后分别进行动态动脉内血压测定、生理试验和放射线核素心室造影。
Carvedilol (CDL) is a new non-cardiac selective beta-blocker with vasodilating action, which is effective in treating angina pectoris. This article studies the product of essential hypertension patients with left ventricular function, physiological test blood pressure and 24-hour blood pressure. Methods: 12 patients with essential hypertension. Three weeks after discontinuation of all antihypertensive drugs, patients with systolic blood pressure> 160 mmHg or diastolic blood pressure> 100 mmHg after 15 minutes of rest in supine position. First oral CDL25mg 2 times a day, 2 weeks later if the diastolic blood pressure ≥ 95mmHg or diastolic blood pressure before treatment did not fall more than 20mmHg, then increase the dose of CDL to 50mg twice daily for 2 weeks. Before treatment, the first dose after 2 hours and after treatment were measured arterial blood pressure, physiological tests and radionuclide ventriculography.