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目的探讨血浆脑钠肽(BNP)水平与重症脓毒症患者预后的相关性研究。方法 90例脓毒症患者,将所有患者按进院14 d预后状况分为存活组70例和死亡组20例,存活组根据APACHEⅡ评分分为轻度组20例,中度组30例,重度组20例。比较各组血乳酸、血浆BNP、APACHEⅡ评分及左室射血分数(LVEF)情况。结果存活组血乳酸、血浆BNP、APACHEⅡ评分及LVEF优于死亡组,差异有统计学意义(P<0.05),轻度组LVEF和BNP与中度组对比差异无统计学意义(P>0.05),轻度组血乳酸和APACHEⅡ与中度组对比,差异有统计学意义(P<0.05);轻度组和中度组各项指标与重度组对比,差异有统计学意义(P<0.05)。结论脓毒症患者血浆BNP水平升高不但能够知道患者心肌已经受到一定程度的损坏,而且可以作为脓毒症患者危险分层以及预后的重要的指标。
Objective To investigate the correlation between plasma brain natriuretic peptide (BNP) level and the prognosis of severe sepsis patients. Methods Seventy patients with sepsis were divided into two groups: survival group (70 cases) and death group (20 cases) according to the prognosis of 14 days. The survival group was divided into mild group (20 cases), moderate group (30 cases), severe group Group of 20 cases. Blood lactic acid, plasma BNP, APACHEⅡscore and left ventricular ejection fraction (LVEF) were compared between groups. Results The levels of Lactate, Plasma BNP, APACHEⅡ and LVEF in survival group were significantly higher than those in death group (P <0.05). There was no significant difference between mild group and moderate group (P> 0.05) , Mild blood lactic acid and APACHE Ⅱ compared with the moderate group, the difference was statistically significant (P <0.05); mild and moderate indicators of each group compared with the severe group, the difference was statistically significant (P <0.05) . Conclusions Elevated BNP levels in patients with sepsis not only indicate that the patient’s myocardium has been damaged to a certain extent, but also serve as an important indicator of risk stratification and prognosis in patients with sepsis.