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1.本文报告我院1961年3月至1977年12月用大剂量男性素治疗慢性再障47例的疗效分析。基本治愈4例、缓解7例、显效22例、稳定6例、无效8例,有效共39例,有效率82.9％。 2.治疗后先有网织红细胞升高。血相恢复到正常的顺序是白细胞、血红蛋白、红细胞、血小板。部分病人治疗后可见到骨髓增生程度改善及粒+红/淋巴的比值升高。网织红细胞持续高值、输血需要的减少、临床症状改善和出血倾向的减轻,常为血相进步的先兆。 3.随访观察的25例中(占有效组39例的67.6％),出院后血相进一步改善者15例,无变化者6例,退步者2例,死亡2例。大剂量男性素治疗不仅近期疗效较好,远期疗效也比较满意。 4.男性素的副作用有皮肤痤疮、毛细血管扩张、体毛增多变粗、性欲增进、水肿、乳房底盘增大、肝功能异常等;女性可有声音嘶哑变粗、闭经、阴蒂肥大等现象。 5.影响疗效的因素,主要是药物剂量。
1. This article reports from March 1961 to December 1977 in our hospital with high-dose male hormone in the treatment of 47 cases of chronic aplastic anemia analysis. Four patients were cured, seven were relieved, 22 were markedly effective, 6 were stable, 8 were ineffective, and 39 were effective. The effective rate was 82.9%. 2. After treatment, there is reticulocyte elevation. Blood returned to normal order is white blood cells, hemoglobin, red blood cells, platelets. Some patients can be seen after treatment to improve the degree of bone marrow hyperplasia and granule + red / lymph ratio increased. Reticulocyte sustained high value, blood transfusion needs reduction, improvement of clinical symptoms and reduction of bleeding tendency, often for the blood phase of the advancement. Follow-up observed in 25 cases (effective group accounted for 67.6% of 39 cases), after discharge from the hospital to further improve the blood 15 cases, no change in 6 cases, 2 cases of retrogressive, 2 cases of death. Not only the short-term treatment of high-dose male hormone therapy is better, long-term efficacy is also more satisfactory. 4 male prime side effects of skin acne, telangiectasia, body hair increased thickening, sexual desire enhancement, edema, breast enlargement, liver dysfunction, etc .; women may have a hoarse voice, amenorrhea, clitoral hypertrophy and so on. 5 factors that affect the efficacy, mainly drug dose.