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[目的]探讨慢性阻塞性肺疾病(cOPD)继发肺部真菌感染的危险因素。[方法]回顾性分析38例继发肺部真菌感染患者的临床资料。[结果]COPD继发肺部真菌感染临床表现缺乏特异性,容易漏诊,病原菌以白色念珠菌为主。广谱抗生素、糖皮质激素及呼吸机辅助呼吸的应用,低蛋白血症及高龄是继发真菌感染的主要危险因素。[结论]降低COPD继发真菌感染的主要途径是合理使用抗生素、糖皮质激素及呼吸机,预防医源性感染.提高患者免疫力。
[Objective] To explore the risk factors of pulmonary fungal infection secondary to chronic obstructive pulmonary disease (cOPD). [Methods] The clinical data of 38 patients with secondary pulmonary fungal infection were retrospectively analyzed. [Results] The clinical manifestations of pulmonary fungal infection secondary to COPD lack of specificity, easy to missed diagnosis, mainly Candida albicans pathogens. Broad-spectrum antibiotics, glucocorticoids and ventilator-assisted breathing applications, hypoproteinemia and advanced age are the major risk factors for secondary fungal infections. [Conclusion] The main way to reduce the secondary fungal infection of COPD is to use antibiotics, glucocorticoids and ventilator reasonably to prevent iatrogenic infection and improve the immunity of patients.