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为探讨急性心肌梗塞（ＡＭＩ）患者周围血中内皮素（ＥＴ）及一氧化氮（ＮＯ）的浓度变化及意义，选择发病１２ｈ 内入院的ＡＭＩ患者３８ 例，另选心绞痛患者２３ 例及正常对照者３０ 例，分别测定周围血中ＥＴ、ＮＯ的含量。结果提示：ＡＭＩ患者ＥＴ 浓度明显高于心绞痛组及正常对照组，各组ＥＴ浓度变化依次为ＡＭＩ组＞ 心绞痛组＞ 正常组，ＮＯ浓度则呈相反变化。表明ＮＯ与ＥＴ的平衡失调参与了心肌缺血损伤的发生、发展过程。
To investigate the changes and significance of endothelin (ET) and nitric oxide (NO) in peripheral blood of patients with acute myocardial infarction (AMI), 38 patients with AMI admitted within 12 hours of onset, 23 patients with alternative angina pectoris and normal controls 30 cases, respectively, the determination of peripheral blood ET, NO content. The results suggest that ET concentration in patients with AMI is significantly higher than that in patients with angina pectoris and normal control group. The changes of ET concentration in each group are AMI group, angina pectoris group and normal group, while the NO concentration changes in the opposite direction. Show that imbalance of NO and ET involved in the occurrence and development of myocardial ischemic injury.