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目的:了解我院不动杆菌临床分布及耐药情况,指导临床合理使用抗菌药物。方法:采用ATB-Expresson细菌鉴定及药敏系统对2005年1月~2009年1月门诊和住院患者各类标本分离到的不动杆菌进行鉴定和药敏实验。结果:共分离到不动杆菌118株,以鲍曼不动杆菌和洛菲不动杆菌为主。其耐药性以氨卞西林/舒巴坦的耐药性最高达80%;对庆大霉素、妥布霉素、复方新诺明的耐药率>60%;对哌拉西林、替卡西林、环丙沙星、头孢他定、头孢吡肟、耐药率次之>40%。对复方替卡西林、哌拉西林-三唑巴坦、阿米卡星耐药率均>30%;对亚胺培南和美罗匹宁的耐药率最低为5%。结论:不动杆菌是医院感染的常见菌,耐药情况严峻,应对其进行严密监测,并规范使用抗菌药物,延缓其耐药性的产生。
Objective: To understand the clinical distribution and drug resistance of Acinetobacter in our hospital and to guide the rational use of antibiotics in clinical practice. Methods: The ATB-Expresson bacterial identification and drug sensitivity system were used to identify and detect the susceptibility of Acinetobacter isolated from various samples of outpatients and inpatients from January 2005 to January 2009. Results: A total of 118 Acinetobacter isolates were isolated, mainly Acinetobacter baumannii and Acacia rhofae. The drug resistance to ampicillin / sulbactam resistance up to 80%; resistance to gentamicin, tobramycin, cotrimoxazole resistance rate of> 60%; piperacillin, for Carracillin, ciprofloxacin, ceftazidime and cefepime, the rate of resistance was> 40%. The drug resistance rate to compound ticarcillin, piperacillin-tazobactam and amikacin was> 30%, and the lowest resistance rate to imipenem and meloxicine was 5%. Conclusion: Acinetobacter nosocomial infection is a common bacteria, drug-resistant situation is severe, should be closely monitored, and regulate the use of antimicrobial agents, delay the emergence of drug resistance.