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Objective To determine the impact of circulating LH concentrations du ring cont rolled ovarian hyperstimulation on the outcome of IVF. Design Retrospective stud y. Setting University hospital. Patient(s) Two-hundred seventy women who had a short stimulation protocol with GnRH antagonist and ovarian stimulation with rec ombinant FSH (rFSH). Intervention( s)GnRHantagonist and rFSH were administered S C; blood samples were collected on the day of GnRH antagonist administration, 1 day after, and on the day of hCG administration. Main outcome measure(s) A thres hold of 0.5 IU/L on the day of hCG was chosen to discriminate between women with LH concentrations ≤0.5 IU/L (group A, n = 119) or >0.5 IU/L (group B, n = 151) . Result(s) The two groups were comparable with regard to the clinical parameter s. In group A, significantly lower LH concentrations were observed on day 9 of t he cycle and on the day of hCG administration. The numbers of oocytes retrieved, embryos obtained, and embryos cryopreserved were significantly higher in group A compared with group B. The proportion of clinical pregnancieswas similar in th e two groups (21.1%vs. 22.7 %per ET). Conclusion(s) In GnRH antagonist and rFS H protocols, suppressed serum LH concentrations do not have any influence on the final stages of follicular maturation, pregnancy rates, or outcomes.
Objective To determine the impact of circulating LH concentrations du ring cont rolled ovarian hyperstimulation on the outcome of IVF. Design Retrospective stud y. Setting University hospital. Patient (s) Two-hundred seventy women who had a short stimulation protocol with GnRH antagonist and ovarian stimulation with rec ombinant FSH (rFSH). Intervention (s) GnRHantagonist and rFSH were administered SC; blood samples were collected on the day of GnRH antagonist administration, 1 day after, and on the day of hCG administration. Main outcome measure (s) A thres hold of 0.5 IU / L on the day of hCG was chosen to discriminate between women with LH concentrations ≦ 0.5 IU / L (group A, n = 119) or> 0.5 IU / L (group B, n = 151). Result (s) The two groups were comparable with regard to the clinical parameter s. In group A, significantly lower LH concentrations were observed on day 9 of t he cycle and on the day of hCG administration. The numbers of oocytes retrieved, embryos were obtained , and embryos cr Conclusions (s) In GnRH antagonist and rFS H protocols, suppressed serum LH-concentration (21.1% vs. 22.7% per ET) do not have any influence on the final stages of follicular maturation, pregnancy rates, or outcomes.