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目的:探讨脑卒中合并肺部感染患者血清降钙素原(PCT)水平监测对指导临床抗生素使用的作用。方法:选取住院治疗的100例脑卒中合并肺部感染患者,采用随机数字表法分为研究组和对照组各50例,研究组患者应用PCT指标指导抗生素治疗,对照组依据我国抗生素使用指南使用抗生素治疗,记录两组患者治疗效果的差异。结果:研究组的住院时间、住院费用、抗生素治疗时间、抗生素治疗费用均显著低于对照组(P<0.05),治疗30 d后两组患者的病死率、NIHSS评分、Barthel指数比较差异均无统计学意义(P>0.05),两组患者治疗后第1、第3、第7天及停用抗生素时的PCT和C反应蛋白(CRP)水平差异均无统计学意义(P>0.05),两组患者治疗过程中各类抗生素使用率差异无统计学意义(P>0.05)。结论:通过监测脑卒中合并肺部感染患者血清PCT水平指导临床抗生素应用,能够达到与常规抗生素应用相同的效果,同时可以缩短治疗时间和降低费用。
Objective: To investigate the effect of serum procalcitonin (PCT) level monitoring on clinical antibiotic use in patients with stroke and pulmonary infection. Methods: 100 hospitalized patients with stroke complicated with pulmonary infection were selected and randomly divided into study group and control group with 50 cases in each group. Patients in study group were treated with antibiotics in accordance with PCT guidelines, while those in control group were used according to guidelines for antibiotics in our country Antibiotic treatment, record the differences between the two groups of patients treated. Results: The hospitalization time, hospitalization expense, antibiotic treatment time and antibiotic treatment cost in the study group were significantly lower than those in the control group (P <0.05). There was no significant difference in mortality, NIHSS score and Barthel index between the two groups after 30 days of treatment (P> 0.05). There was no significant difference in the levels of PCT and C-reactive protein (CRP) between the two groups on the 1st, 3rd, and 7th day after antibiotic treatment (P> 0.05) There was no significant difference in the usage of various antibiotics between the two groups during treatment (P> 0.05). CONCLUSIONS: Monitoring clinical PCT levels in patients with stroke and pulmonary infection can guide the clinical use of antibiotics and achieve the same results as conventional antibiotics, while reducing treatment time and costs.