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双异内吡胺(Disopyramide)是一有用的抗心律失常药,通常对室性心律失常比室上性者更为有效,可静脉及口服给药,适用于紧急和长期治疗。然而,动物实验显示双异丙吡胺可引起剂量依赖性冠状血流减少。相反,利多卡因在人体中可使冠状动脉灌注量增加。本文旨在评价静脉给予双异丙吡胺对冠状动脉血流量、心肌耗氧量、心肌对乳酸盐的提取以及全身血液动力学的作用。为了比较,对静脉注射利多卡因后的另一组病人进行了同样的测定。方法:用双异丙吡胺的10例中4例、用利多卡因的10例中7例有心肌梗塞史。所有病人由临床病史及血管造影证实有重度冠状动脉病变。喷血分
Disopyramide is a potent antiarrhythmic drug that is usually more effective against supraventricular ventricular arrhythmias and can be administered intravenously and orally for emergency and long-term treatment. However, animal experiments show that dipipridylamine can cause dose-dependent coronary blood flow reduction. In contrast, lidocaine increases coronary perfusion in the body. This article aims to evaluate the effect of intravenous bisoprogram on coronary blood flow, myocardial oxygen consumption, myocardial lactate extraction and systemic hemodynamics. For comparison, the same assay was performed on another group of patients after intravenous injection of lidocaine. METHODS: Four of 10 patients treated with dipipridylamine and 7 of 10 patients treated with lidocaine had a history of myocardial infarction. All patients were confirmed by clinical history and angiography with severe coronary lesions. Spurt blood points