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目的探讨低能量雷射治疗难治性口腔溃疡的临床效果及对T细胞亚群、疼痛指数的影响。方法选择2013年1月—2014年12月收治的80例难治性口腔溃疡患者作为研究对象,随机分为对照组和观察组各40例。对照组采取常规治疗,维生素B2、维生素C各20 mg/次,口服,1次/d;于溃疡面涂抹2.5%碳酸氢钠溶液,淡盐水漱口;观察组在对照组基础上行低能量雷射治疗,两组均治疗3 d。比较两组临床疗效、治疗前后T细胞亚群指标、视觉模拟评分法(visual analogue scale,VAS)评分。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组总有效率为95.0%,显著高于对照组的75.0%,差异有统计学意义(P<0.05)。观察组治疗第1、3天VAS评分分别为(2.35±1.40)、(1.12±0.56)分,均明显低于对照组的(4.03±1.79)、(2.01±1.04)分,差异均有统计学意义(均P<0.05)。观察组治疗后CD3+、CD4+、CD4+/CD8+水平分别为(69.7±6.0)%、(45.5±4.1)%、(1.8±0.5)%,与治疗前的(54.2±5.0)%、(35.0±2.4)%、(1.3±0.6)%比较差异均有统计学意义(均P<0.05)。对照组治疗后CD3+、CD4+水平分别为(61.2±4.5)%、(41.0±3.2)%,与治疗前的(54.1±5.3)%、(34.8±2.2)%比较差异均有统计学意义(均P<0.05)。两组治疗后CD3+、CD4+、CD4+/CD8+水平比较差异均有统计学意义(均P<0.05)。结论低能量雷射治疗难治性口腔溃疡疗效明显,能显著减轻疼痛症状,改善机体细胞免疫功能。
Objective To investigate the clinical effects of low-energy laser treatment on refractory oral ulcer and its effect on T cell subsets and pain index. Methods Eighty patients with refractory oral ulcer admitted from January 2013 to December 2014 were selected as study subjects and randomly divided into control group and observation group of 40 cases each. The control group received routine treatment, vitamin B2, vitamin C each 20 mg / times, orally, once / d; smear 2.5% sodium bicarbonate solution on the ulcer surface, salt water gargle; observation group in the control group based on low energy Ray Shoot treatment, both groups were treated 3 d. The clinical curative effect, index of T cell subsets before and after treatment, visual analogue scale (VAS) score were compared. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate in the observation group was 95.0%, which was significantly higher than that in the control group (75.0%), the difference was statistically significant (P <0.05). The VAS scores of the observation group on the 1st and 3rd day were (2.35 ± 1.40) and (1.12 ± 0.56) points, respectively, which were significantly lower than those in the control group (4.03 ± 1.79 and 2.01 ± 1.04) Significance (all P <0.05). The levels of CD3 +, CD4 + and CD4 + / CD8 + in the observation group were (69.7 ± 6.0)%, (45.5 ± 4.1)% and (1.8 ± 0.5)%, )%, (1.3 ± 0.6)%, respectively (all P <0.05). The levels of CD3 + and CD4 + in the control group were (61.2 ± 4.5)% and (41.0 ± 3.2)%, respectively, which were significantly different from those before treatment (54.1 ± 5.3) and (34.8 ± 2.2)% P <0.05). The levels of CD3 +, CD4 + and CD4 + / CD8 + in both groups after treatment were significantly different (all P <0.05). Conclusion Low-energy laser treatment of refractory oral ulcer has obvious curative effect, can significantly reduce pain symptoms and improve cellular immune function.