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目的观察复方丹参滴丸联合西药治疗急性缺血性脑卒中患者的临床治疗效果。方法选取2014年1月—2017年1月住院治疗的急性缺血性卒中患者200例,随机分为实验组与对照组各100例。对照组均给予以常规对症治疗,实验组在对照组的基础上给予复方丹参滴丸治疗,10丸/次,3次/d。4周为1个疗程,治疗2个疗程。比较这两组血小板参数、血脂参数变化情况及临床疗效,并观察不良反应发生情况。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,实验组血小板最大聚集率、血浆血栓素B2水平、平均血小板体积、甘油三酯(TG)、总胆固醇(TC)与低密度酯蛋白(LDL-C)[(31.9±8.4)%、(92.6±21.5)ng/L、(44.3±8.1)fl、(1.1±0.5)mmol/L、(3.8±0.5)mmol/L、(2.2±0.5)mmol/L]均显著低于对照组[(42.5±9.7)%、(105.2±30.1)ng/L、(53.3±6.9)fl、(2.0±0.6)mmol/L、(5.4±0.6)mmol/L、(5.4±0.6)mmol/L],差异有统计学意义(均P<0.05),高密度酯蛋白(HDL-C)升高的幅度[(1.9±0.5)mmol/L]大于对照组[(1.1±0.4)mmol/L],差异有统计学意义(P<0.05);实验组患者治疗总有效率85%明显高于对照组68%,差异有统计学意义(P<0.05);实验组和对照组患者治疗不良反应分别为6.0%,14.0%,差异有统计学意义(P<0.05)。结论复方丹参滴丸治疗急性缺血性脑卒中,较纯西医用药更有效,可改善血小板参数及血脂水平并降低不良反应,且安全性较高。
Objective To observe the clinical effect of Fufang Danshen Diwan combined with western medicine in the treatment of acute ischemic stroke patients. Methods A total of 200 acute ischemic stroke patients admitted to hospital from January 2014 to January 2017 were randomly divided into experimental group (100 cases) and control group (100 cases). The control group were given conventional symptomatic treatment, the experimental group in the control group on the basis of compound Danshen dripping pills treatment, 10 pills / time, 3 times / d. 4 weeks for a course of treatment, treatment 2 courses. Compare the two groups of platelet parameters, changes in blood lipid parameters and clinical efficacy, and to observe the incidence of adverse reactions. Measurement data were compared using t test, count data were compared using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the maximum platelet aggregation rate, plasma thromboxane B2 level, mean platelet volume, triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL-C) , (92.6 ± 21.5) ng / L, (44.3 ± 8.1) fl, (1.1 ± 0.5) mmol / L, (3.8 ± 0.5) mmol / L and (2.2 ± 0.5) mmol / L] (5.4 ± 0.6) mmol / L, (5.4 ± 0.6) mmol / L and (5.4 ± 0.6) mmol / L compared with those in the control group (42.5 ± 9.7% vs 105.2 ± 30.1 ng / L, (P <0.05). The increase of high density lipoprotein (HDL-C) was (1.9 ± 0.5) mmol / L higher than that of the control group [(1.1 ± 0.4) mmol / L] , The difference was statistically significant (P <0.05). The total effective rate of the experimental group was 85% higher than that of the control group (P <0.05), the difference was statistically significant (P <0.05). The adverse reactions of the experimental group and the control group were respectively 6.0%, 14.0%, the difference was statistically significant (P <0.05). Conclusion Compound Danshen dripping pills for acute ischemic stroke, more effective than pure Western medicine, can improve platelet parameters and blood lipid levels and reduce adverse reactions, and high safety.