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目的探讨PCT在诊断新生儿脓毒症的阳性临界值。方法采用德国BRAHMS PCT-Q检测试剂盒,对2423住院新生儿进行PCT水平检测,其中新生儿脓毒症阳性625例,非脓毒症1798例。结果用PCT诊断新生儿脓毒症的灵敏度、特异度、阳性预测值、阴性预测值、阳性似然比、阴性似然比和粗符合率分别为96.84%、91.40%、81.03%、98.71%、11.26、0.035和92.90%。脓毒症组PCT阳性率明显高于非脓毒症组(P<0.05)。PCT≥0.5ng/ml为阳性标准对新生儿脓毒症的诊断有很高的特异性和敏感性。结论 PCT≥0.5ng/ml可作为临床诊断新生儿脓毒症的实验室检查的早期特异性阳性临界值。
Objective To explore the positive critical value of PCT in the diagnosis of neonatal sepsis. Methods 2423 in-hospital newborns were tested for PCT level using the German BRAHMS PCT-Q test kit, of which 625 were neonatal sepsis positive and 1798 were non-sepsis. Results The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio and crude coincidence rate of neonatal sepsis diagnosed by PCT were 96.84%, 91.40%, 81.03%, 98.71% 11.26, 0.035 and 92.90%. The positive rate of PCT in sepsis group was significantly higher than that in non-sepsis group (P <0.05). PCT≥0.5ng / ml is a positive standard for the diagnosis of neonatal sepsis with high specificity and sensitivity. Conclusion PCT≥0.5 ng / ml can be used as the early specific positive cut-off value for clinical examination of neonatal sepsis clinically.