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探讨肺癌患者胸水中腺癌细胞的超微结构特点及与反应性间皮细胞的鉴别,分别对41例肺腺癌患者胸水中的癌细胞和对照组10例胸水中反应性间皮细胞进行超微结构对比观察。肺腺癌细胞表面的微绒毛、核凹陷和胞浆内的分泌颗粒、连接复合体及板层小体等超微结构均有助于与反应性间皮细胞的鉴别,其中短棒状微绒毛作为腺癌细胞形态特征标志,检出率为92.7%,如果再结合观察细胞间的连接复合体,其检出率高达95.1%。在常规细胞病理学诊断的基础上,再进行电镜观察,对肺癌患者胸水中腺癌细胞的诊断及鉴别诊断具有重要的临床应用价值。
To investigate the ultrastructural characteristics of adenocarcinoma cells in pleural effusion of lung cancer patients and the identification of reactive mesenchymal cells, respectively, in 41 cases of pleural effusion in patients with lung adenocarcinoma and 10 cases of pleural fluid reactive mesothelial cells Microstructure comparison observation. Microvilli on the surface of lung adenocarcinoma cells, nuclear degeneration and intracellular secrete particles, connective complexes and lamellar bodies and other ultrastructure contribute to the identification of reactive mesothelial cells, which short rod-shaped microvilli as Adenocarcinoma cells morphological characteristics of the logo, the detection rate was 92.7%, if combined with the observation of cell-junction complex, the detection rate as high as 95.1%. On the basis of routine cytopathological diagnosis, further electron microscopic observation has important clinical value in the diagnosis and differential diagnosis of adenocarcinoma cells in pleural effusion of lung cancer patients.