近十几年来，不少学者使用经过纯化的天然水蛭素或重组水蛭素进行了一系列的动物实验和临床研究［１，２］，结果发现，作为凝血酶特异性抑制剂的水蛭素，有强的抗凝血和抗血栓形成作用。我们通过十二指肠给药方式研究重组水蛭素的抗凝血和抗血栓形成作用，为口服水蛭素给药提 In the recent decade, many scholars conducted a series of animal experiments and clinical studies using purified natural hirudin or recombinant hirudin [1, 2]. As a result, it has been found that hirudin, which is a thrombin-specific inhibitor, has Strong anticoagulant and antithrombotic effects. We studied the anticoagulant and antithrombotic effects of recombinant hirudin by duodenal administration, administered oral hirudin