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作者用伺服零测压系统测定麻醉家兔软脑膜微血管压,观察去交感神经支配和地塞米松对急性缺氧家兔脑血管纵向压降分布的影响.在模拟4000m高原,单纯急性缺氧组的软脑膜微动脉(直径为50～70μm)平均压(Pp)显著降低,测压点上、下游血管压降比显著增高,颈内动脉血流量明显增加。切除颈上交感神经节组4000m高原Pp值显著高于单纯急性缺氧组,上、下游压降比显著低于单纯急性缺氧组,Pp值和上、下游压降比与本组缺氧前比均无差异。地塞米松组的变化趋势与去交感神经支配组相同。三组动物缺氧前的Pp值之间和上、下游压降比之间无差异。结果表明:(1)在PaO_2、PaCO_2和Bp正常时,交感神经和地塞米松对家兔脑血管纵向压降分布没有影响;(2)急性缺氧时家兔脑血管纵向压降重分布,测压部位上游压降增大,下游压降减少,这个改变有交感神经参与;(3)地塞米松可抑制缺氧时脑血管纵向压降重分布,它对急性高山病的防治作用可能部分与之有关。
The authors measured the effects of denervated sympathetic innervation and dexamethasone on the distribution of longitudinal blood pressure in acute hypoxic rabbits by servo zero pressure measurement system.At the simulated 4000m plateau, (Pp) of the pia mater arterioles (diameter 50 ~ 70μm) were significantly decreased. The pressure drop of blood vessels in the upper and lower reaches of the pressure vessel was significantly increased, and the blood flow of the internal carotid artery was significantly increased. The Pp value of 4000m plateau in the superior cervical sympathetic ganglia group was significantly higher than that in the acute hypoxia group, and the pressure drop ratio in the upper and lower reaches was significantly lower than that in the acute hypoxia group. The Pp value, No difference compared to no. Dexamethasone group trends and de-sympathetic innervation group the same. There was no difference between the Pp values of the three groups of animals before hypoxia and the pressure drop ratio of the upper and lower animals. The results showed that: (1) Sympathetic nerve and dexamethasone had no effect on longitudinal blood pressure distribution in rabbits when PaO_2, PaCO_2 and Bp were normal; (2) longitudinal pressure drop of rabbits in acute hypoxia was redistributed, Pressure drop upstream pressure increases, the downstream pressure drop decreases, this change has sympathetic involvement; (3) dexamethasone can inhibit the longitudinal vascular pressure redistribution of hypoxia, its role in the prevention and treatment of acute mountain disease may be part of Related to it.