论文部分内容阅读
甲氰咪胍(Cimetidine,Tagamet,以下简称甲咪)作为一种有效的H_2受体拮抗剂,不仅对于治疗消化性溃疡近期疗效显著,优于一般抗酸解痉药,而且对上消化道出血、胃泌索瘤、糜烂性食管炎、返流性食管炎及某些非消化系疾病如带状泡疹等也有较好疗效。随着甲咪在临床上广泛应用,其不良反应及急性毒性逐渐被加以注意并陆续予以报道,其发生率约22～24.9％。现将近来有关甲咪的不良反应及急性毒性综述如下: 一、中枢神经系统的毒性反应 甲咪引起中枢神经系统的副反应最为多见,发生率各报道不一。Schentag等报道为5.8～17％,1980年世界自动报告系统总结发生率为7.3/10万。
Cimetidine (Cimetidine, hereinafter referred to as Jia Mi) as a potent H 2 receptor antagonist, not only for the treatment of peptic ulcer recent significant effect, superior to the general antacid antispasmodic drugs, and upper gastrointestinal bleeding , Gastric tumors, esophageal erosions, reflux esophagitis and some non-gastrointestinal diseases such as band-like herpes also have a good effect. With the wide application of methylphenidate clinically, its adverse reactions and acute toxicity have been gradually noticed and reported one after another, with the incidence of about 22-24.9%. Now the recent adverse effects of methylmercury and acute toxicity are summarized as follows: First, the toxicity of the central nervous system Jiama caused by the central nervous system, the most common side effects, the incidence of different reports. Schentag et al reported between 5.8% and 17%. In 1980, the world automatic reporting system concluded that the incidence was 7.3 / 100,000.