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骨髓炎目前仍是困扰骨科医师的一大难题。大量研究表明，遗传因素可能在骨髓炎的发病中起重要作用。单核苷酸多态性(SNPs)作为第3代遗传标记，在骨髓炎遗传易感性方面的研究越来越受关注。对骨髓炎易感性基因的单核苷酸多态性进行深入研究，有助于探索骨髓炎预防、诊断和治疗的新策略。本文就目前基因SNPs与骨髓炎易感性的研究进展作一综述。“,”Osteomyelitis (OM) is still a major problem for orthopedists. Numerous studies have shown that genetic factors may play an important role in the pathogenesis of OM. As a third generation genetic marker, single nucleotide polymorphisms (SNPs) have received increasing attention from scholars who are studying genetic susceptibility to OM. In-depth research on the SNPs of susceptibility genes will help to explore new strategies for prevention, diagnosis and treatment of OM. This article reviews the research advances concerning gene SNPs and OM susceptibility.