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目的:探讨首次热性惊厥(FC)患儿的复发情况及引起复发的相关因素。方法:回顾性分析首次FC患儿100例的临床资料,采用Spearman单因素与多元Logistic回归分析的方法,对首次FC患儿复发的影响因素进行分析。结果:本组100例首次FC患儿中,复发59例,未复发41例。复发组与未复发组在年龄、体温、FC分型、围生期异常、剖宫产及惊厥家族史方面均有明显差异(P<0.05);引起首次FC复发的危险因素有年龄(β=0.929,S.E.=0.572,Wald=52.391,P<0.05,OR=2.78)、围生期异常(β=0.772,S.E.=0.689,Wald=34.027,P<0.05,OR=1.77)、体温(β=0.934,S.E.=0.301,Wald=12.382,P<0.05,OR=2.32)及惊厥家族史(β=0.661,S.E.=0.381,Wald=19.929,P<0.05,OR=2.09)。结论:引起首次FC患儿复发的相关因素包括年龄、围生期异常、体温及惊厥家族史等,应对这些因素进行严密地观察,以降低FC患儿的复发率。
Objective: To investigate the recurrence and relapse-related factors in children with first febrile seizures (FC). Methods: A retrospective analysis of 100 cases of first-time patients with FC clinical data, the use of Spearman single-factor and multiple logistic regression analysis of the impact of the first recurrence of FC children were analyzed. Results: The first group of 100 patients with FC recurrence in 59 cases, 41 cases did not relapse. There were significant differences in age, body temperature, FC classification, perinatal abnormalities, cesarean section and family history of convulsion (P <0.05) between the recurrent group and the non-recurrent group. The risk factors for the first recurrent FC were age (β = 0.929, SE = 0.572, Wald = 52.391, P <0.05, OR = 2.78) and the perinatal abnormalities (β = 0.772, SE = 0.689, Wald = 34.027, , SE = 0.301, Wald = 12.382, P <0.05, OR = 2.32) and family history of convulsion (β = 0.661, SE = 0.381, Wald = 19.929, P <0.05, OR = 2.09). CONCLUSIONS: The factors that contribute to the first recurrence of FC include age, perinatal abnormalities, body temperature and familial history of convulsions. These factors should be closely observed to reduce the recurrence rate in children with FC.