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我们于1979年开始进行人脑恶性胶质细胞瘤体外培养,其中命名为SHG-44(Suzhou Human Glioma)的细胞已培养了二年半,生长旺盛,现传至80代。其LDH同功酶呈M型,并检出S-100蛋白。裸鼠及大白鼠的移植成功率分别为60%和69%,病理学所见与原来的人脑胶质瘤细胞形态相似。本文报告其建系过程和有关特征。
We started in vitro culture of glioblastoma of the human brain in 1979, in which the cells named SHG-44 (Suzhou Human Glioma) have been cultured for two and a half years and have been growing vigorously until 80 passages. The LDH isozyme was M-type, and S-100 protein was detected. The success rates of transplantation in nude mice and rats were 60% and 69%, respectively. The pathological findings were similar to the original human glioma cells. This article reports its build-up process and related features.