癫是一种常见的神经系统疾病,发病率(2～5)/1 000人,严重影响患者的生活、工作和学习,成为中枢神经系统疾病中的一大顽疾。因此,对癫发病机制的研究成为当今国际神经科学领域的重要课题。通过对动物模型和人类癫手术切除的海马标本研究,癫的发病机制可能是由于兴奋性异常增高、抑制机制不足或两者兼有之而导致的癫灶内神经元兴奋性过高,从而导致这些神经元的失控性自发性异常放电,进而引起了癫的反复性发作。 Epilepsy is a common neurological disease, the incidence of (2 ~ 5) / 1 000 people, seriously affecting the patient’s life, work and study, become a major disease in the central nervous system diseases. Therefore, the study of the pathogenesis of epilepsy has become an important topic in the field of international neuroscience. In animal models and human epileptic resection of hippocampal specimens of the study, the pathogenesis of epilepsy may be due to abnormal excitability, lack of suppression mechanisms or both caused by the excitability of neurons in the epileptic foci , Resulting in uncontrolled spontaneous abnormal discharge of these neurons, which in turn causes recurrent seizures of epilepsy.