脑保护剂依达拉奉(edaravone,注射剂30mg,日本三菱制药公司生产)致急性肾衰已写入说明书中。日本厚生省药品医疗器械安全信息部称,说明书这一修改是基于收到的3份由急性肾衰致死的报告,其死亡原因疑是使用了依达拉奉。依达拉奉于2001年6月投入市场,上市第一年约有99000名病人使 Brain protectant Edaravone (injection 30mg, produced by Japan’s Mitsubishi Pharmaceutical Co.) caused acute renal failure has been written in the instructions. Japanese Ministry of Health, Medicines and Medical Devices Safety Information Department said the manual is based on the changes received three reports of death from acute renal failure, the cause of death is suspected of using edaravone. Edaravone was put on the market in June 2001 with about 99,000 patients in its first year of listing