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1978年以来,美国用二丙基醋酸(VPA)治疗癫痫。本文报告一例孕妇服用 VPA 引起畸胎。结合以前报告的数例和动物试验,证明 VPA 是一种人类致畸剂。病历摘要:23岁,第一胎,因原发性癫痫于孕前6个月至整个孕期服用 VPA250mg,日3次。妊娠初3个月因晨吐短期服醋氯酚(Acetamino-phen)、Tigan 和 Macdecon。因泌尿系感染服磺胺二甲嘧啶、增效剂和氨基苄青霉素。无烟酒嗜好。爱人25岁,无毒物接触史,家族中无明显畸形患者。妊娠期36周羊水过多,自然娩出一女婴,无
Since 1978, the United States has treated epilepsy with dipropylacetic acid (VPA). This article reports a case of pregnant women taking VPA teratogenic. Combined with previously reported cases and animal tests, VPA is a human teratogen. Medical record summary: 23 years old, the first child, because of primary epilepsy in pre-pregnancy 6 months to take the entire pregnancy VPA250mg, 3 times a day. Acetamino-phen, Tigan and Macdecon for short-term morning sickness during the first trimester of pregnancy. Due to urinary tract infection sulfamethazine, synergist and ampicillin. Non-smoking alcohol hobby. Love 25 years old, non-toxic contact history, no obvious deformity in the family of patients. 36 weeks of pregnancy polyhydramnios, a baby was delivered naturally, without