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目的探讨六味地黄方加味联合保妇康栓治疗肝肾阴虚型老年性阴道炎(SV)的临床疗效。方法选取2014年3月—2015年3月忻州市第二人民医院收治的肝肾阴虚型SV患者90例,随机分为A、B、C组,各30例。A组患者予以六味地黄方加味联合保妇康栓治疗,B组患者予以保妇康栓治疗,C组患者予以六味地黄方加味治疗。观察3组患者治疗7d局部症状体征和中医症候的临床疗效、治疗后3d局部症状体征和中医症候的临床疗效、复发率及不良反应发生情况。结果 A、B组患者治疗7d局部症状体征的临床疗效比较,差异无统计学意义(P>0.05),A、B组患者治疗7d局部症状体征的总有效率高于C组,差异有统计学意义(P<0.05);A、C组患者治疗7d中医症候的总有效率高于B组,差异有统计学意义(P<0.05),A、C组患者治疗7d中医症候的临床疗效比较,差异无统计学意义(P>0.05);A、B组患者治疗后3d局部症状体征的临床疗效比较,差异无统计学意义(P>0.05),A、B组患者治疗后3d局部症状体征的总有效率高于C组,差异有统计学意义(P<0.05);A、C组患者治疗后3d中医证候的总有效率高于B组,差异有统计学意义(P<0.05),A、C组患者治疗后3d中医证候的临床疗效比较,差异无统计学意义(P>0.05);A组患者复发率低于B组,差异有统计学意义(P<0.05),A、C组患者复发率比较,差异无统计学意义(P>0.05),B、C组患者复发率比较,差异无统计学意义(P>0.05);3组患者均未发生严重不良反应。结论六味地黄方加味联合保妇康栓治疗肝肾阴虚型SV的临床疗效显著,且复发率低,不良反应少。
Objective To investigate the clinical effects of Liuwei Dihuang Recipe combined with Baofukang suppository in treating senile vaginitis (SV) of liver and kidney yin deficiency type. Methods From March 2014 to March 2015, 90 patients with liver-kidney deficiency type SV in Xinzhou Second People’s Hospital were randomly divided into A, B and C groups, with 30 cases in each group. Patients in group A were treated with Liuwei Dihuang decoction combined with Baofukang suppository, patients in group B were treated with Baofukang suppository, and patients in group C were treated with Liuweidihuang decoction. The clinical curative effect of local symptoms and signs and symptoms of Chinese medicine on the 7th day after treatment were observed. The clinical efficacy, recurrence rate and adverse reactions of local symptoms and signs and TCM symptoms after 3 days were observed. Results There was no significant difference in the clinical efficacy of local symptoms and signs between groups A and B for 7 days (P> 0.05). The total effective rate of local symptom and signs for 7 days in groups A and B was higher than that in group C (P <0.05). The total effective rate of TCM symptoms in group A and group C was significantly higher than that in group B at 7 days (P <0.05), and the clinical efficacy of TCM symptoms in group A and group C was significantly higher than that in group B There was no significant difference between the two groups (P> 0.05). There was no significant difference in the clinical curative effect of local symptoms and signs between group A and group B after 3 days of treatment (P> 0.05) The total effective rate was higher than that of C group (P <0.05). The total effective rate of TCM syndromes in A and C groups was significantly higher than that of B group after treatment (P <0.05) There was no significant difference in the clinical efficacy of TCM syndromes after 3 days of treatment between A and C groups (P> 0.05). The recurrence rate of A group was lower than that of B group (P <0.05) There was no significant difference in relapse rate between group C and group C (P> 0.05), but there was no significant difference between group B and group C (P> 0.05). No serious adverse reactions occurred in all three groups . Conclusion Liuweidihuang Decoction combined with Baofukang suppository has significant clinical effect in treating SV with deficiency of liver and kidney, with low recurrence rate and few adverse reactions.