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虽然一般认为血清丙氨酸转氨酶(ALT)测定不能预测慢性肝炎患者的病变活动度,但这一问题在抗-HCV阳性患者中尚未被完全阐朋。此种情况可能符合临床情况,因为在常规评定干扰素治疗HCV相关慢性肝炎的疗效时,仅测定血清ALT。作者对288例无症状抗-HCV阳性者进行了研究,其中15例血清ALT持续正常(半年内连续6次检测均正常),而其余患者ALT升高(为正常值上限的1.5～4倍以上)。所有患
Although serum alanine aminotransferase (ALT) assays are not generally predictive of disease activity in patients with chronic hepatitis, this issue has not been fully elucidated in anti-HCV positive patients. This condition may be clinically relevant because only serum ALT is measured when routinely assessing the efficacy of interferon in the treatment of HCV-associated chronic hepatitis. The authors studied 288 asymptomatic anti-HCV positive individuals, of whom 15 had normal ALT (6 consecutive tests within 6 months), while others had elevated ALT (1.5 to 4 times the upper limit of normal) ). All suffering