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目的探讨根除幽门螺杆菌(Hp)在疣状胃炎亚离子凝固术后的疗效。方法选取经胃镜确诊的合并Hp感染的疣状胃炎患者52例,随机分成两组,治疗组及对照组各26例。两组均给予亚离子凝固术,术后均给予奥美拉唑20mg每天2次口服,共4周。另外治疗组给予阿莫西林1000mg,早晚各1次口服,克拉霉素500mg,早晚各1次口服,共1周。两组患者均于治疗结束后复查胃镜和Hp测定,并随访12个月,对患者的症状缓解程度、创面黏膜愈合情况及复发情况进行评价。结果治疗组和对照组所有患者均完成整个研究。治疗组有23例(88.5%)Hp得到根除(3例Hp未根除的患者纳入对照组)。创面黏膜愈合情况治疗组95.7%(22/23),对照组79.3%(23/29),差异有统计学意义(P<0.01)。12个月复查胃镜,治疗组无1例复发,对照组有4例复发(P<0.01)。结论疣状胃炎在亚离子凝固术后根除Hp可促进黏膜修复,避免或减少复发。
Objective To investigate the efficacy of eradication of Helicobacter pylori (Hp) after sub-ion coagulation in verrucous gastritis. Methods Fifty-two patients with verrucous gastritis confirmed by gastroscope with Hp infection were randomly divided into two groups, the treatment group and the control group, with 26 cases in each group. Both groups were given sub-ion coagulation surgery, were given omeprazole 20mg orally twice daily for 4 weeks. In addition, the treatment group was given amoxicillin 1000mg, morning and evening 1 times orally, clarithromycin 500mg, 1 time sooner or later oral, a total of 1 week. Both groups were examined by endoscopy and Hp after the end of treatment, and were followed up for 12 months, the degree of symptom relief, wound mucosal healing and recurrence were evaluated. Results All patients in the treatment and control groups completed the study. Hp was eradicated in 23 patients (88.5%) in the treatment group (3 patients with unexplained Hp were included in the control group). The mucosal wound healing in the treated group was 95.7% (22/23) in the treatment group and 79.3% (23/29) in the control group, the difference was statistically significant (P <0.01). Gastroscopy was performed at 12 months. No recurrence was found in the treatment group, and 4 cases relapsed in the control group (P <0.01). Conclusion Vermilion gastritis can eradicate Hp after sub-ion coagulation and promote mucosal repair to avoid or reduce recurrence.