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As the huge computation and easily trapped local optimum in remanufacturing closed-loop supply chain network (RCSCN) design considered,a genetic particle swarm optimization algorithm was proposed.The total cost of closed-loop supply chain was selected as fitness function,and a unique and tidy coding mode was adopted in the proposed algorithm.Then,some mutation and crossover operators were introduced to achieve discrete optimization of RCSCN structure.The simulation results show that the proposed algorithm can gain global optimal solution with good convergent performance and rapidity.The computing speed is only 22.16 s,which is shorter than those of the other optimization algorithms.