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目的探讨中西医联合干预、预防或减轻经皮肾镜取石围手术期全身炎症反应综合征的效果。方法模拟人体进行微通道经皮肾镜取石术围手术期处理和手术过程,选择雄性新西兰大白兔制作动物模型,实验组20只,对照组5只;2组均灌服盐酸左氧氟沙星胶囊25 mg,1日1次;于术后0.5 h开始,实验组静脉注射痰热清注射液0.3~0.5 m L·(kg·d)-1,1日1次,均连用7 d,对照组注射等量0.9%氯化钠。选不同时间段抽取外周静脉血,监测白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)及甲状腺激素(TT4、TT3)的变化。结果 IL-2、TT4、TT3的变化是先降后升,而IL-6、TNF是先升高后回落;实验组恢复程度明显好于对照组。结论中西医联合干预经皮肾镜取石围手术期对预防或减轻全身炎症反应综合征起积极的作用。
Objective To explore the combined Chinese and Western medicine intervention to prevent or reduce percutaneous nephrolithotomy perioperative response to systemic inflammatory response syndrome. Methods To simulate the percutaneous nephrolithotomy with micro-channel percutaneous nephrolithotomy in the human body, the male New Zealand white rabbits were selected to make the animal model, 20 in the experimental group and 5 in the control group. The two groups were given 25 mg of levofloxacin hydrochloride capsules, On the 1st day after operation, the experimental group started intravenous injection of Tanreqing Injection 0.3 ~ 0.5 m L · (kg · d) -1 for 1 day and 0.5 mg once daily for 7 days. The rats in the control group were injected with equal volume 0.9% sodium chloride. Peripheral venous blood was collected at different time points to monitor the changes of interleukin-2, interleukin-6, tumor necrosis factor and thyroid hormones (TT4, TT3). Results The changes of IL-2, TT4 and TT3 were firstly decreased and then increased, while the levels of IL-6 and TNF were increased first and then decreased. The recovery of experimental group was significantly better than that of control group. Conclusion Integrative Chinese and Western medicine percutaneous nephrolithotomy perioperative period to prevent or reduce systemic inflammatory response syndrome plays a positive role.